Renew iv Blog


NAD+ Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death

July 8, 2021

Abstract

In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD+) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including sirtuins, poly(ADP-ribose) polymerases and cyclic ADP-ribose synthetases. The connection with aging and age-associated diseases has led to a new wave of research in the cardiovascular field. Here, we review the basics of NAD+ homeostasis, the molecular physiology and new advances in ischemic-reperfusion injury, heart failure, and arrhythmias, all of which are associated with increased risks for sudden cardiac death. Finally, we summarize the progress of NAD+-boosting therapy in human cardiovascular diseases and the challenges for future studies.

Read the full article here:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438569/

Welcome to the Renew iv Blog

We bring you information about wellness.

Follow us

Stay connected

Sign up for email updates to receive all of our latest news

  • This field is for validation purposes and should be left unchanged.


Statements provided have not been evaluated by the Food and Drug Administration. We do not diagnose, prevent or cure any medical conditions. All infusions and injections are administered by state licensed registered nurses and overseen by our Medical Director, Dr. Daniel La Perriere, a board certified MD, Certified Functional Medicine practitioner through the IFM and Founder of Colorado Concierge Functional Medicine. Some health conditions contraindicate the use of our products. Please consult your physician before beginning injections of any kind.